PCN73 UTILISATION OF ANTINEOPLASTIC AGENTS IN SLOVAK REPUBLIC

Consumption of Medicaments in the Slovak Republic

High consumption of medicaments places a heavy burden on public health systems. Several major national surveys have documented important increases in the misuse and abuse of several prescription drugs (1). Analysing consumption and prescription of drugs have been conducted in several studies (2, 3). This study aimed to analyze the consumption of individual classes of medicaments in the Slovak R...

Antineoplastic Agents

Antibacterial activities of antineoplastic agents.

Fourteen antineoplastic agents were examined for in vitro antibacterial activity against 101 aerobic and anaerobic bacterial isolates representing indigenous human microflora and selected opportunistic pathogens. Only 5-fluorouracil, mitomycin, and etoposide demonstrated inhibitory effects at achievable plasma concentrations, while the remaining drugs lacked appreciable antibacterial activities.

Dietary intake of sulphites by children in the Slovak Republic.

The mean dietary intake of sulphites by Slovak children aged 7 to 10 years was estimated. Calculations were based on a food model of a specific boarding-school in January, May, July and October while respecting the scientifically recommended dietary allowances. It was assumed that sulphites were used in the widest possible range of foods and at maximum permitted levels. Due to this fact and sin...

Handling of injectable antineoplastic agents.

Although the clinical toxicity of antineoplastic drugs has been well documented there is little or no information on the problems that may arise on the handling and mishandling of such agents. This paper attempts to highlight the importance of taking precautions to prevent adverse effects resulting from contact with cytotoxic drugs during handling and to suggest a practical guide for the handli...